Modeling spontaneous breast cancer metastasis to the bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity

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BACKGROUND

Breast cancer hits 1 woman in 8, and its most common metastatic site is the bone (70%). A major hurdle to overcome breast cancer mortality is the lack of understanding of dynamics leading to the spread of breast cancer cells to the bone.

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OUR AIM

To shed light on the bone metastatic process, B2B aims to develop a breakthrough technology that for the first time dissects the steps of spontaneous breast cancer metastasis to the bone and captures the 3D complexity of the process.

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OUR APPROACH

The B2B device includes macro-size organoids from breast tumor and bone, assembled together with a macro-to-micro vascular network. This level of physiological complexity is required to capture the key elements of the metastatic process.

THE DEVICE: HOW IT WORKS

The unique device includes a 3D patient-derived primary lesion growing within its own self-assembled micro-vascular capillary network connected to a functional bioprinted macro-vascular tree. The circulatory system mimics the features of human blood vessels feeding and connecting living-tumor cells from breast cancer to the target metastatic tissue: the bone, represented by a marrow-containing ossicle.

3D printer

B2B partners

Greece

Italy

Netherlands

Switzerland

United Kingdom